Common Side Effects of Hormone Replacement Therapy

Published on 1 July 2025 at 16:00

Common Side Effects when using HRT

Understanding the Side Effects of HRT: What to Expect and How to Manage Them

Hormone Replacement Therapy (HRT) can be life-changing for many women navigating the challenges of perimenopause and menopause. It helps ease symptoms like hot flushes, night sweats, mood swings, and brain fog by replenishing declining hormone levels. But like any treatment, HRT can come with side effects - some mild, some more noticeable. Thankfully, for most ladies, these side effects generally settle after three months.

Common Side Effects of Oestrogen

Oestrogen is often the main component of HRT. While many tolerate it well, some may experience side effects as detailed within the table.

Common Side Effects of Progestogen 

If you still have a uterus, progestogen is added to protect the womb lining. Possible side effects  are shown in the Progestogen table. 

Some women are particularly sensitive to progestogen and may benefit from body identical options like micronised progesterone (e.g. Utrogestan) or a hormonal coil. 

Bleeding

Light bleeding can be quite common when starting HRT or adjusting the dose, and it  usually settles within 3 to 6 months. However, if the bleeding is heavy, happens after  sex, or continues beyond six months, it’s important to speak to your GP, as they may  recommend an examination or further tests to rule out other causes. 

Combined HRT? 

Combined HRT (oestrogen and progestogen) can cause a mix of the usual side effects  mentioned earlier. It’s also quite normal to have some irregular bleeding during the first  4 to 6 months, particularly with continuous use. 

When to Seek Help 

Most side effects are temporary, but you should speak to a healthcare professional if: 

  • Bleeding continues beyond 6 months 
  • Side effects are severe or impact your quality of life
  • You’re unsure whether symptoms are from HRT or menopause itself 

 

Possible Oestrogen side effects Try any of the below suggestions to help with side effects
Fluid retention Reduce dose
Breast tenderness/swelling Change route
Headchaes/increase in migraines Change method
Nausea/Dyspepsia Try & work out which hormone is causing the effect
Bloating
Itching
Leg cramps
Irregular vaginal bleeding (esp. in the first few months)
Dizziness
Mood changes

Many of these symptoms improve as your body gets used to the treatment, but if they continue, adjusting the dose or trying a different form - like switching from tablets to  patches or gel - can often make a difference.


Possible progestogen side effects Try any of the below suggestions to help with side effects
Fluid retention Change type
Breast tenderness/swelling Reduce dose (only under specialist guidance)
Headaches Change route
Mood swings Alter duration
PMT-like symptoms
Acne/greasy skin
Change in vaginal discharge
Dizziness
Itching
Spotting or bleeding between periods

Conclusion 

While responses to HRT can vary from person to person, some side effects may resolve naturally over time, whereas others may require adjustments. Our goal is to see noticeable improvement within approximately three months.

HRT is a highly individual experience - what works well for one person might not be the  best fit for another. Finding the right type, dose, and way of taking it can take time, but  with the right guidance, it can be truly life changing. If you’re thinking about starting HRT  or having trouble with side effects, get in touch with us and we can help you explore  your options with confidence and support.

 


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